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PLATELET-RICH PLASMA (PRP)

Platelet-Rich Plasma, also known as PRP, provides the combined benefits of antiinflammation and tissue regeneration in the horse. Appropriately, this product is widely used in the equine veterinary industry.

Numerous growth factors have been used in the horse with the intention of enhancing synthesis and reducing breakdown of tendon/ ligament tissue pursuant to injury. Historically, these growth factors have been harvested from bone marrow and/or fat aspirates, which also contain increased concentrations of stem cells.

PRP

Platelet-rich plasma (PRP) is an autologous concentration of platelets in a small volume of plasma.

Plasma is the straw-colored liquid in which blood cells are suspended. PRP is generated through relatively simple centrifugation of blood. Because it is a concentration of platelets, it is also a concentration of seven fundamental protein growth factors known to be secreted by platelets in response to wound healing. PRP also contains proteins known to promote cell adhesion during tissue rebuilding.

Autologous versus Allogeneic

The primary difference between allogeneic and autologous cells lies in their source. Allogeneic therapies are manufactured in large batches from unrelated donor tissues (such as bone marrow) whereas autologous therapies are manufactured as a single lot from the patient being treated.

Platelets perform many functions in the body, including formation of blood clots and release of growth factors into wounds. The rationale for the use of PRP as a treatment strategy for tendonitis (tendon damage) and desmitis (ligament damage) stems from the increased platelet release of multiple growth factors in response to an injury. Two additional incentives for using PRP include its relative ease of collection and the unlikelihood that it will result in immune rejection since it is autologous (produced from the patient's own blood).

PRP

At The Atlanta Equine Clinic, PRP has been used to successfully treat the following soft tissue injuries:

• Tendon Strain

• Muscle Strain

• Ligament Strain

• Joint Capsular Laxity

PRP has also been used to treat intraarticular injuries. Examples include arthritis, arthrofibrosis, articular cartilage defects, meniscal injury, and chronic synovitis (joint inflammation).

Click HERE to review common joint therapies in the horse.

Click HERE to review the basics of degenerative joint disease (DJD) in the horse.